ALLOX is a spin-off of the Centre for Genomic Regulation (CRG) and draws on the expertise and technology developed in the lab of Ben Lehner. The company was born out of the realisation that combining systematic mutagenesis, high-throughput phenotyping and biophysical modelling has the potential to revolutionise drug development but also transform biotechnology in general. In February 2025 we will be relocating to a new incubation space in the Barcelona Science Park (surrounded by 3 research institutes and over 70 different companies), and our immediate goal is to identify allosteric switches in all proteins and then leverage this unprecedented resource to rapidly develop novel medicines to treat human diseases. Our long-term vision is to become a leader in programmable biology, building the next generation of tools to predict, design and engineer new protein functions. We believe in a future where humanity will be able to harness the power of biology to solve our most pressing issues. We are expanding our interdisciplinary team with highly motivated individuals who are excited by this bold vision, share our sense of urgency, but are not willing to compromise on integrity. At ALLOX the success of our revolutionary scientific approach is as important to us as our mission to create a healthy, honest and respectful culture, both internally and with our partners.

For additional information, please visit: https://www.allox.bio/

ALLOX is seeking a highly motivated and ambitious Computational Chemist to join our growing startup and spearhead our in-house drug discovery efforts. As a key member of our multidisciplinary team you will play a pivotal role in translating the allosteric maps generated by our platform into actionable chemical strategies for modulating protein function and addressing unmet medical needs. Your primary responsibility will be to leverage ALLOX’s unique data on protein function to design and optimise novel small-molecule allosteric modulators. This will involve: (1) applying virtual screening techniques to identify promising drug candidates that bind to allosteric sites, (2) performing molecular dynamics simulations and free energy calculations to assess the stability and activity of these molecules, (3) making use of structure-based drug design and cheminformatics approaches to optimise their pharmacological properties, and (4) collaborating closely with experimental scientists to validate and refine your computational predictions. The ideal candidate possesses a strong background in computational chemistry and drug discovery, with demonstrated experience in techniques such as virtual screening, molecular docking, pharmacophore modeling, and QSAR. A deep understanding of protein structure and function, as well as familiarity with allosteric regulation, is essential. Excellent communication and collaboration skills are crucial, as you will be working closely with both computational and experimental scientists to drive our drug discovery efforts forward. If you are a passionate and results-oriented scientist eager to contribute to the development of novel therapeutics and thrive in a dynamic and collaborative environment, we encourage you to apply. Join ALLOX and help us revolutionize drug discovery by unlocking the potential of allosteric modulation!

To determine starting pay, we consider multiple job-related factors including a candidate’s skills, education and experience, the level at which they are actually hired, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data.

This role is eligible for participation in our Annual Performance Bonus Plan (based on company goals by role level and annual company performance) and all employees are offered Equity, subject to the terms of those plans and associated policies.

In addition, ALLOX also provides our employees:

• 25 days annual leave (excluding public holidays)
• Paid parental leave
• Free drinks, snacks and regular team meals 

This position is available for full-time on-site work at Barcelona Science Park, a hybrid model combining on-site and remote work, or fully remote work depending on the role and your individual circumstances. We are open to discussing the best option for you during the interview process.

The startup nature of ALLOX provides multiple growth opportunities into other areas of the company. As one of the early employees at ALLOX, your work will have a direct impact on the foundation of a groundbreaking new approach to biotechnology.

Apply for this job here. The interview process includes a take-home assignment to assess your practical skills.

The closing date for applications is February 28th, 2025. We encourage applicants to submit their application at the earliest opportunity as the closing date may be brought forward if a high volume of applications are received.

*Please note jobs may be taken down from our website, this does not mean they have been filled. This is to maintain our candidate experience for current applicants. If you are in the interview process and would like to request a copy of the job description, reach out to your recruiting contact.